Penn came twice to his colony, and never tarried long within it.  His first voyage was in the fall of 1682, and he left in August of 1684. He returned for a short spell in 1692, and at that time was accompanied by  James Logan [our direct via the Howard Ascendancy] , a man of modest means who gained employment as Penn's secretary,  functioned as steward of Pennsylvania on behalf of Penn in Penn's absence, and grew to be the wealthiest man in all the colonies at his zenith.  It is during Penn's first  visit to his colony that Penn supposedly signed a treaty with the Lenni Lenape Indians at Shackamaxon.  No copy of this agreement exists, but there is a wampum belt that is said to have been given to Penn by the natives at this time. Colonial Historian "Francis Jennings believes that Penn signed the treaty and never broke it, but that his less scrupulous successors destroyed the document, presumably so that they could renege on its provisions."³. The earliest treaty document to which we can actually refer is the Treaty dated July 15, 1682 , in which Penn brokered with Idquahon and several others amongst the Lenape leadership for land pertaining to them.  In 1683 he brokered more land transactions with these native peoples, while evidencing undertanding of the Lenape and the Iroqois Confederacy of New York to whom the Lenape were subjugated.  "The treaty of 1701 is both the first full treaty text that remains extant (there exist parts of earlier ones), and the last agreement brokered directly by Penn rather than his agents. It also capped a major power play: 'It conveyed land, controlled trade, and arranged juridical relationships, all at the expense of New York and New York's partners, the Iroquois Five Nations' (Jennings 205). As he had done before, Penn rewarded 'his' Indians. His policies helped make Pennsylvania, in the words of the missionary John Heckewelder, 'the last, delightful asylum' for Native Americans (Jennings, 207). Penn's successors were much less fair and scrupulous in dealing with the Indians. The ink was barely dry on the 1701 treaty when Penn's secretary and family steward, James Logan , began to devise ways to reclaim land set aside for the Susquehannocks and the Delaware. "³

Footnote Two:
"Initially, Penn dealt with the Unami (Turtle Totem) Lenni Lenape (Delaware) tribe when he came to Pennsylvania, and the Delaware Chief, Tammany, played a prominent role in the early treaties negotiated with Penn. Although the real 
Tammany's mark appeared on only two treaties (June 23, 1683 and June 15, 1692), he was destined to become a legendary  figure in United States and Pennsylvania history and folklore.[6] Tradition has it that Tammany's name 
meant "the affable" and that he was one of the Delaware Indians who welcomed William Penn on his arrival in 
America, October 27, 1682.[7] By July 6, 1694 in a meeting between the Provincial Council of Pennsylvania and a delegation of Indians, Tammany had become a strong supporter of the whites and their policies.[8] From these 
facts and folklore, a legendary Tammany was   constructed in the early eighteenth century that was the white 
man's friend and counselor. "

From AN AMERICAN SYNTHESIS The Sons of St. Tammany or Columbian Order . [ the footnotes as evident in the text takent from "an American Synthesis" can be accessed at the link given in source] 

The time between right to survey and right to the land west of the Susquehanna lagged nearly 15 years during which period settlement west of the Susquehanna was occuring, but the Penn heirs were not profiting from the settlement, and the area involved dispute with Maryland regarding where exactly the boundary of the two colonies lay. 

"Sir william Keith...Lt Governor of the province of Pennsylvania, ...was anxious to hinder these encroachments on what he believed to be the property of the heirs of Penn....the lands had not, as yet, been purchased from the Indians by the propretor of Pennsylvania, and much less by that of Maryland......the policy of Penn ever had been to grant no rights to lands, and to permit no settlements on them, until purchased of the Indians.....
"[Keith consulted] ...the Indians in the neighborhood of the Suquehanna, and ...consulted or held a treaty with the Indians at Conestogoe on the 15th and 16th of June, 1722, when they counselled together concerning the making of a survey  for the use of Springett Penn, the grandson, and as then believed, the heir of William Penn" ⁸. Present at the meeting was the Govenor with two others on the part of the Colony, and the chiefs of the Conestogoes, Shawanas and Ganaways, among them Tawena⁸... Tawena's  name is also mentioned in the Madame Ferree story on her arrival to the Pequea Valley East of the Susquehanna in then Chester, now Lancaster County, found east of the Susquehanna and in about 1712]

"...Part of Chester Countyís western frontier at the beginning of the 18th century [desired] Settlement along the Susquehanna was important to Pennsylvaniaís future development not only because of the boundary dispute with Maryland that precipitated Cresap's War (1731-1736) but also because the Susqehanna was a trade route  that provided direct accesss from Pennsylvaniaís hinterland to the West and to the Chesapeake, The heartland  of the American colonies. ì¹⁰
 

8. History of York County from its erection to the present time; [1729-1834] By W. C. Carter & A. J. Glossbrenner.
New edition; with Additions Edited by A. Monroe Aurand, Jr. Privately Printed: The Aurand Press: Harrisburg, Pa. 1930; page 3-9 ìManor of Springettsburyî

10. From:Hopkins, Leroy. ìBlack Eldorado on the Susquehanna: The Emergence of Black Columbia, 1726-1861î, Journal of the Lancaster County Historical Society. Vol 89, pp 110-132  Transcription available at Link

First William Penn and later "his heirs and their representatives, negotiated  formally with the Indians, and purchased from them land already nominally theirs . As settlement along the coast grew in size and number, the need for westward expansion became apparent, and in 1722 the Indians were asked for, and gave, permission to survey the land beyond the Susquehanna River. "  ² It was at this time that  " a tract about 6 miles wide and 15 miles long and including the site now occupied by the City of York, was surveyed and named Springettsbury Manor, for Springett Penn, the grandson of the Founder. " ²  14 years later 

" In the summer of 1736 the sachems (i.e. rulers) of the Five Nations met in the country of the Onandagoes (i.e. in the region of the present-day state of New York) and decided to review the treaties that had been made between them and the colonists. They then traveled to Philadelphia and renewed old treaties of friendship with the Penn family. The Treaty of the Five  Nations, signed by the twenty-three Indian chiefs present, granted to the Penns, among other boundaries: "all the lands lying on  the west side of the said river (i.e. the Susquehanna) to the setting of the sun." ²⁷  Ben Franklin's "Gazettle"  informs "Conrad Weiser learned, about 1 September, that a group of Six Nations chiefs were on their way to Pennsylvania. They were guided to James Logan's home at Stenton where, 28 September, the treaty began. Franklin reported the presence of the Indians in the 7 October Gazette. The treaty continued at the Friends' Great Meeting House in Philadelphia and concluded on 14 October, with the two sides renewing the earlier treaty of friendship, 1732. A Treaty of Friendship held with the Chiefs of the Six Nations at Philadelphia (1737) was the first of a series of Indian treaties printed by Franklin. Then the chiefs met privately with John Penn. He reminded them that they had previously sold all the land along the Susquehanna and asked why they had lately laid claims to those lands. On 11 October the Indians confirmed the sale. The Gazette, 14 October, celebrated Pennsylvania's peaceful Indian policy. At Conrad Weiser's home, 25 October, the chiefs also sold land along the Delaware River below the Kittatinny Hills, and a group of four chiefs warned the Proprietors that the Delaware Indians no longer owned any land and were not to be trusted. "²⁸ 

" Onandagoe ,  Seneca, Oneida and Tuscarora nations [of the Six Nations] signed a new treaty of peace and deeded to the Penns, 'all the river Susquehanna and all land lying on the west side of said river to the setting of the sun...'. "  ²
 
 

In 1637, "the Onandagoe, Seneca (see also this alternate Seneca link ), Oneida and Tuscarora  [all members of the Iriquois nation]   "signed a new treaty of peace and deeded to the Penns, 'all the river Susquehanna and all land lying on the west side of said river to the setting of the sun...' "²